江西中医药大学学报2016年12月第28卷第6期
JOURNAL OF JIANGXI UNIVERSITY OF TCM2016 Yol. 28 No. 6
★ 陈平u**杨志波3***王万春4颜纯钏4张艳晖1宋淑华1王志强2陈思婷2吴事仁2(1•南昌市中西医结合医院南昌330003;2.江西中医药大学南昌330004;3.湖南中医药大学第二附属医院 长沙410005 ;4.江西中医药大学附属医院南昌330006)
青年之友>优化股权结构
摘要：目的：本研究主要探讨湿疹纳米乳膏的抗炎实验，初步探讨其慢性湿疹的作用机制，为湿疹纳米乳膏慢性湿疹提供实验依据和理论依据。方法：采用大剂量致敏，小剂量多次激发的方法造慢性湿疹动物模型，以尤卓尔软膏为对照，观察湿疹纳米乳膏对该模型的作用。结果：湿疹纳米乳膏可抑制二硝基氯苯所导致小鼠耳结痂形成、抑制小鼠耳肿胀情况、减轻真皮淋巴细胞的浸润。结论：低中高浓度的湿疹纳米乳膏均对慢性湿奢模型有抗炎效果，中农度疗效尤佳。智能材料
王坤和蔡慧近况关键词：湿疹纳米乳膏；慢性湿疹；抗炎实验
中图分类号:R285 文献标识码:B
Eczema Nano Cream for the Treatment of Chronic Eczema Anti - inflammatory Experiments
CHEN Ping12, Y ANG Zhi - bo3, W ANG Wan - chun4, YAN Chun - chuan4, ZHANG Yan - hui1 ,SONG Shu - hua1, W ANG ZW - qiang2, CHEN Si - ting2, W U Shi - ren2
1. Nanchang Hospital o f Integrated Chinese and Western M edicine, Nanchang 330003 , China；牛顿冷却定律
2. Jiangxi University o f Traditional Chinese M edicine, Nanchang 330004, China；
3. The Second A ffiliated Hospital o f H unan University o f Chinese M edicine f Changsha 410005 ,CAiraa；
4. The A ffiliated Hospital o f Jiangxi University o f Traditional Chinese M edicine, Nanchang 33Q006 f China.
Abstract ： Objective ：This research is for the purpose of confirming the effect of Eczema Nano emulsion Cream in Anti - inflammatory, and to explore its action mechanism. In the meanwhile, offering experimental data to the research of Eczema Nano emulsion Cream curing Chronic Eczema. Methods ：T he use of large doses of allergens, t he method of making low - dose and multiple challenges in animal models of chronic eczema to Youzhuoer ointment as a control, to observe the effect of eczema cream Nano model. Results：Eczema Nano cream inhibits dinitrochlor
obenzene mouse ear caused by scab, inhibition of mouse ear swelling circumstances,reduce dermal lymphocytic infiltration. Conclusion ：N ano eczema cream low in the high concentrations of mice with chronic dermatitis and eczema have some anti - inflammatory effects, c oncentration in the best curative effect.
Key words:Eczema Nano Cream; Chronic Eczema; Anti — inflammatory Experiment
跨越百年的美丽主要内容慢性湿疹是皮肤科的常见病，该病病程长，易反 复发作，中医学中又名“湿疮”[1]。占皮肤科门诊 量的20%[2]，由于慢性湿疹瘙痒难耐，反反复复发 作，带给患者身心极大痛苦[3]。
目前西医外治慢性湿疹以糖皮质激素软膏为 主，可快速起效，但易产生依赖，停药后容易反复，可 能产生素沉着、诱发皮肤感染等不良反应，甚至产 生全身性副作用[4]。中医药外用慢性湿疹疗
*基金项目：国家‘‘十一五”科技支撑计划项目（2008BAI33B042)。
**第一作者：陈平(1985—），女，江西高安人，主治中医师。研究方向：湿疹。
***通信作者：杨志波（1956 —），男，湖南津市人，教授，博士生导师。研究方向：湿疹、银屑病。E-mail:d r.yang888@126。
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